Breast Cancer

Breast Cancer

Substantial investment in breast cancer research has led to advances in screening, treatment, and prevention over the last four decades. As a result, over 90 percent of breast cancers are diagnosed at an early age, surgery has become less invasive, and the development of more effective therapies have boosted cure rates to current highs. Crucial insights from genetics research have also led to new, preventive drugs and surgeries that have helped to reduce the risk of occurrence for women who are at high risk for the disease, including those predisposed as a result of genetic mutations.

Today, nine out of ten women are alive five years after diagnosis and mortality has fallen by more than a third since the 1980s. However, more research is still needed to develop better treatments for advanced stages and currently resistant forms of breast cancer, and to address profound racial disparities in breast cancer mortality. 

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1894

Radical mastectomy introduced as a treatment for breast cancer

Radical mastectomy introduced as a treatment for breast cancer

In 1894, William Halsted publishes a theory that breast cancer spreads from the primary tumor to the rest of the body through the surrounding tissue and lymph nodes. This insight led to his development of the Halsted radical mastectomy, in which a surgeon removes the full breast, the surrounding lymph nodes and chest muscles. Although the approach improved cure rates and resulted in fewer nearby cancer recurrences than previous surgical approaches, it caused significant side effects and cosmetic disfigurement that seriously diminished the quality of life for thousands of women. Over the next century, breast cancer surgeries become vastly more conservative and effective, enabling many women to avoid mastectomy altogether.