Cervical Cancer

Cervical Cancer

Cervical cancer is unique among common cancers: it has a single, known cause – the human papillomavirus (HPV) – and highly effective screening and prevention tools have the potential to virtually eliminate deaths from the disease. Research into HPV and cervical cancer detection has helped to reduce U.S. cervical cancer death rates by nearly 70 percent since the 1950s.

Despite these advances, nearly 12,000 American women are still diagnosed with cervical cancer annually, primarily because they do not receive routine screening and follow-up care. Moreover, with limited access to vaccines, screening, and treatment in low resource countries, annual mortality is 250,000 worldwide.

While screening and vaccination remain the first lines of defense, researchers are also working to improve treatments for women diagnosed with cervical cancer. 

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1999

DNA test approved to detect HPV virus, the virus that causes cervical cancer

DNA test approved to detect HPV virus, the virus that causes cervical cancer

The FDA approves a new test to detect the strains of the human papillomavirus (HPV) that are known to cause cervical cancer. The test, which identifies DNA from these high-risk virus types, is approved for use in women age 30 and older in combination with the Pap test, and for women of all ages who have an abnormal Pap test result. Subsequent studies show that HPV testing alone is significantly more sensitive at detecting advanced pre-cancers than the Pap test (96 percent vs. 55 percent), but HPV testing results in more false positive results. When combined, the HPV test and Pap tests are found to be 100 percent sensitive for identifying women at risk for cervical cancer. For women younger than age 30, however, the Pap test alone is sufficient and combined screening is not recommended.

Widespread screening reduces cases of advanced cervical cancer in older women

Widespread screening reduces cases of advanced cervical cancer in older women

A study shows that Medicare coverage for cervical cancer screening in women over age 65 led to a 19 percent reduction in cervical cancer diagnoses in this group since 1990, enabling detection of more lesions in their precancerous stages, before they progressed to cancer. Current screening guidelines state that screening can be safely stopped in women over age 65 or 70 who have had three or more consecutive normal Pap test results and who have not had an abnormal screening result within the past 10 years.

1998

NCI recommends chemotherapy-radiation combination for invasive cervical cancer

NCI recommends chemotherapy-radiation combination for invasive cervical cancer

Badge indicating that research was paid for using federal funds

The National Cancer Institute issues an alert recommending that physicians consider adding chemotherapy to radiation therapy for women being treated for invasive cervical cancer (cancer that has spread within the cervix or pelvis). This updated approach is based on several randomized trials showing that women lived longer when treated with both radiation and chemotherapy, compared to those treated with the prior standard of radiation or surgery alone.

New liquid-based Pap tests introduced

New liquid-based Pap tests introduced

FDA approves two new liquid-based Pap tests. Whereas conventional tests involve smearing a swab of cervical cells on a slide, in the new tests, the swab is placed into a special preservative solution. These liquid tests provide a clearer, easier-to-read sample for pathologists to review under a microscope, compared to the traditional method.

1990

U.S. government funds cervical cancer screenings for underserved women

U.S. government funds cervical cancer screenings for underserved women

Badge indicating that research was paid for using federal funds

The Breast and Cervical Cancer Mortality Prevention Act of 1990 provides access to free or low-cost breast and cervical cancer screenings to underserved women across the country. Since its inception, this program run by the U.S. Centers for Disease Control and Prevention has provided more than 9.2 million breast and cervical cancer screening examinations, and helped diagnose more than 2,554 cases of cervical cancer and 123,563 cervical "pre-cancers."

1988

Standard system established for evaluating Pap test results

1983

HPV virus is discovered to cause cervical cancer

HPV virus is discovered to cause cervical cancer

Researchers led by Harald zur Hausen isolate specific strains of the human papillomavirus (HPV) as the likely cause of cervical cancer, a link that is soon confirmed with additional research. They find that most cervical pre-cancers and cancers contain DNA from the HPV-16 or HPV-18 strains of the virus. Researchers later link additional strains of HPV to cervical cancer, but HPV-16 and HPV-18 have been established as the most virulent. In 2008, Dr. zur Hausen is awarded the Nobel Prize for Medicine or Physiology for his discovery.