Leukemia

Leukemia

Since discovery of the first effective leukemia treatment in the 1940s, researchers have amassed a growing number of therapies to extend survival and cure many different forms of the disease. Research into targeted drugs are also beginning to have a major impact on leukemia treatment.

While certain forms of leukemia can now be cured in up to 95 percent of patients, others are far more challenging and leukemia has proven far more complex than researchers could have imagined in the 1940s. Yet deeper understanding about the disease is fueling the continuous development of new, more effective therapies and is improving survival and quality of life for patients.

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1947

First compound discovered to inhibit growth of cancer

First compound discovered to inhibit growth of cancer

Sidney Farber first discovers that a drug, called aminopterin, can induce remissions in acute lymphocytic leukemia in children. Although these remissions were temporary, this finding leads to the development of a new category of chemotherapy drugs, called antimetabolites, that impair the ability of cancer cells to grow and replicate. Soon, further research shows that a similar drug, called methotrexate, is superior to aminopterin for leukemia treatment. Methotrexate remains in use today.